Home»Prevenzione»Bloccare il tumore agendo sul colesterolo?

Bloccare il tumore agendo sul colesterolo?

Pinterest Google+

La p53, è conosciuta da circa 40 anni, ed è stata una delle prime proteine la cui versione mutata è stata trovata in moltissime forme tumorali. La versione normale funziona da soppressore della crescita, quella mutata, non riuscendo a svolgere i compiti cui sarebbe preposta, agisce da potenziatore della proliferazione.

Tuttavia non erano ancora ben chiari alcuni suoi comportamenti, e soprattutto le relazioni con la cellula che la ospita.

Ora il gruppo di Giannino Del Sal, docente di Biologia applicata dell’università di Trieste e responsabile del Laboratorio di oncologia molecolare del Laboratorio Nazionale CIB dell’Area Science Park, grazie a un programma finanziato con i fondi del 5 per mille assegnato all’Associazione italiana per la Ricerca sul Cancro (AIRC), ha confermato che, come dimostra un numero crescente di studi degli ultimi anni, lo sviluppo, la proliferazione, la metastatizzazione di un tumore è, anche, una questione di meccanica, e di fisica. E che la p53 mutata, per fare danni, ha bisogno di un certo assetto del tessuto.

Questo dipende dalla catena metabolica del colesterolo, alterando quest’ultima, per esempio con le statine, si può evitare che p53 riesca a fare danni: una scoperta importante, che si è guadagnata le colonne di Nature Cell Biology e che ha già portato a sperimentazioni cliniche.

Spiega Del Sal: “Si è capito che p53 mutata, quando si accumula, dà il via a un processo che si autoalimenta e che rende il tumore aggressivo. Al tempo stesso, però, p53 non riesce ad accumularsi se l’ambiente circostante non è favorevole, se la cellula e il tessuto circostante non hanno un certo livello di tensione, una certa rigidità. Ma queste caratteristiche sono regolate dalla via metabolica del colesterolo: per questo, intervenire su questa via vuol dire inibire tutto il processo che permette a p53 di svolgere il suo ruolo. E questo lo si può fare tanto con le statine quanto, probabilmente, con altri composti, che sono già in sperimentazione clinica”.

Del Sal e i suoi collaboratori sono riusciti a scoprire questi complessi rapporti verificando lo stato genetico e molecolare delle cellule malate, soprattutto di uno dei tumori che ancora oggi più sfuggono al controllo della terapia: quello cosiddetto triplo negativo della mammella, ma anche analizzandone, con microscopi a forza atomica e altre tecniche di morfologia e biomeccanica, tutte le caratteristiche fisiche quali, appunto, la rigidità e la durezza. E la relazione tra la particolare consistenza delle masse tumorali, che i medici conoscono molto bene, e la malignità garantita da p53, è emersa con chiarezza.

“Abbiamo studiato moltissimi composti che potessero agire a questo livello, e ne abbiamo selezionati alcuni molto promettenti, oltre alle statine, a conferma dell’importanza di un approccio traslazionale, che parta dalla conoscenza dei meccanismi alla base del cancro per poi riportare prima possibile quanto scoperto alle necessità del paziente e trovare – questa la speranza – nuove vie terapeutiche”.

L’effetto antitumorale delle statine, pur discusso, è noto da molti anni. Ora, grazie ad AIRC e al lavoro di Del Sal, ha anche una spiegazione biologica.

Fonte: Repubblica Salute

Previous post

Facebook, dannoso per per la salute?

Next post

Perché dividere le compresse è sbagliato?


  1. 05/10/2018 at 13:48

    Heya i’m for the primary time here. I came across this board and I in finding It truly useful & it helped me out a lot. I’m hoping to present something back and aid others like you helped me.

  2. 05/10/2018 at 15:34

    Good day! I know this is kinda off topic however I’d figured I’d ask. Would you be interested in trading links or maybe guest authoring a blog article or vice-versa? My site goes over a lot of the same subjects as yours and I believe we could greatly benefit from each other. If you might be interested feel free to send me an email. I look forward to hearing from you! Excellent blog by the way!

  3. 05/10/2018 at 16:18

    magnificent issues altogether, you simply gained a new reader. What may you recommend in regards to your put up that you made a few days ago? Any certain?

  4. 05/10/2018 at 20:44

    I savor, cause I discovered exactly what I was taking a look for. You have ended my 4 day lengthy hunt! God Bless you man. Have a great day. Bye

  5. 09/10/2018 at 16:51

    Nice read, I just passed this onto a colleague who was doing some research on that. And he actually bought me lunch as I found it for him smile Thus let me rephrase that: Thank you for lunch!

  6. 09/10/2018 at 23:38

    Thanks for the good writeup. It if truth be told used to be a leisure account it. Glance complicated to far added agreeable from you! However, how can we be in contact?

  7. 10/10/2018 at 13:18

    Magnificent goods from you, man. I have understand your stuff previous to and you’re just extremely wonderful. I really like what you have acquired here, certainly like what you’re saying and the way in which you say it. You make it enjoyable and you still care for to keep it wise. I cant wait to read far more from you. This is actually a wonderful website.

  8. 10/10/2018 at 13:57

    Lovely site! I am loving it!! Will be back later to read some more. I am bookmarking your feeds also.

  9. 10/10/2018 at 23:31

    Hi there, just become alert to your weblog thru Google, and found that it’s truly informative. I am gonna watch out for brussels. I’ll appreciate in case you proceed this in future. Lots of folks will likely be benefited out of your writing. Cheers!

  10. 11/10/2018 at 23:36

    Simply wish to say your article is as amazing. The clarity in your post is just excellent and i can assume you’re an expert on this subject. Well with your permission allow me to grab your feed to keep up to date with forthcoming post. Thanks a million and please continue the rewarding work.

  11. 12/10/2018 at 4:07

    We’re a gaggle of volunteers and starting a brand new scheme in our community. Your site offered us with useful information to work on. You’ve performed an impressive process and our whole group can be thankful to you.

  12. 12/10/2018 at 8:36

    This is really interesting, You’re a very skilled blogger. I have joined your feed and look forward to seeking more of your fantastic post. Also, I have shared your web site in my social networks!

  13. 12/10/2018 at 16:39

    I have read a few good stuff here. Definitely value bookmarking for revisiting. I surprise how so much effort you set to make any such magnificent informative website.

  14. 13/10/2018 at 11:26

    Some truly nice and useful info on this site, likewise I conceive the style holds excellent features.

  15. 14/10/2018 at 11:50

    I’d must seek advice from you here. Which is not something Which i do! I love reading an article which will make people feel. Also, thank you for allowing me to comment!

  16. 15/10/2018 at 16:07

    That is the appropriate weblog for anyone who wants to find out about this topic. You realize so much its virtually exhausting to argue with you (not that I truly would want…HaHa). You positively put a brand new spin on a subject thats been written about for years. Great stuff, simply great!

  17. 18/10/2018 at 13:03

    You are a very capable person!

  18. 20/10/2018 at 10:47

    Hi there would you mind sharing which blog platform you’re working with? I’m looking to start my own blog in the near future but I’m having a hard time choosing between BlogEngine/Wordpress/B2evolution and Drupal. The reason I ask is because your design seems different then most blogs and I’m looking for something completely unique. P.S Sorry for being off-topic but I had to ask!

  19. 20/10/2018 at 17:59

    There are those who engage in this type of trading without sufficient knowledge; however, there are day traders who make a successful living despite, or perhaps because of, the risks.

  20. 20/10/2018 at 22:32

    fantastic put up, very informative. I wonder why the other experts of this sector don’t understand this. You should continue your writing. I’m sure, you have a huge readers’ base already!

  21. 21/10/2018 at 8:08

    Very well written post. It will be valuable to anybody who employess it, including myself. Keep doing what you are doing – for sure i will check out more posts.

  22. 24/10/2018 at 17:04

    I loved as much as you’ll obtain carried out proper here. The sketch is attractive, your authored material stylish. however, you command get got an edginess over that you wish be turning in the following. ill surely come further in the past once more as precisely the similar nearly a lot steadily inside of case you shield this increase.

  23. Eliaquim Mangala’s calamitous display at the KC Stadium has left Manuel Pellegrini with a dilemma for Manchester City’s Champions League clash with Roma Tuesday night. Eliaquim Mangala could be axed after Manchester City defender’s Hull nightmare 

  24. 07/11/2018 at 14:34

    We are a group of volunteers and opening a new scheme in our community. Your web site offered us with valuable info to work on. You’ve done an impressive job and our entire community will be thankful to you.

  25. 11/11/2018 at 7:15

    What are the hours of work? good site to buy viagra online Chief Financial Officer Miguel Martinez said the rationalefor holding the 30 percent stake in Gas Natural would be lostafter Repsol closes a deal to sell a large part of its naturalliquid gas assets to Royal Dutch Shell.

  26. 11/11/2018 at 7:58

    I’m curious to find out what blog platform you happen to be working with? I’m having some minor security issues with my latest blog and I’d like to find something more safe. Do you have any solutions?

  27. 12/11/2018 at 10:40

    I’m curious to find out what blog platform you have been using? I’m experiencing some small security problems with my latest website and I’d like to find something more safeguarded. Do you have any suggestions?

  28. 13/11/2018 at 8:59

    I just added this site to my feed reader, great stuff. Can not get enough!

Leave a reply

Il tuo indirizzo email non sarà pubblicato.